Researchers discover a protein that regulates the hierarchical organisation of ribosome development
Friday, May 1, 2015 - 05:50
in Biology & Nature
Ribosomes, which use a fixed genetic programme to manufacture cell proteins, also form according to a strict hierarchical plan. In an interdisciplinary approach, the research teams of Prof. Dr. Ed Hurt of the Heidelberg University Biochemistry Center (BZH) and Prof. Dr. André Hoelz of the California Institute of Technology (Caltech) in Pasadena (USA) have decoded the mechanism that regulates this process. They discovered a previously unknown protein that regulates the processes in the cell nucleus that permit the cell to incorporate ribosomal proteins into the developing pre-ribosome in the correct order. The results of their research were published online in Molecular Cell.