NMR 'fingerprinting' for monoclonal antibodies
Wednesday, April 15, 2015 - 08:30
in Health & Medicine
National Institute of Standards and Technology researchers at the Institute for Bioscience and Biotechnology Research have demonstrated the most precise method yet to measure the structural configuration of monoclonal antibodies (mAbs), an important factor in determining the safety and efficacy of these biomolecules as medicines. Monoclonal antibodies are proteins manufactured in the laboratory that can target specific disease cells or antigens (proteins that trigger an immune reaction) for removal from the body. The method described in a recent paper may soon help manufacturers and regulators better assess and compare the performance and quality of mAbs.