Optical microangiography as a noninvasive method for in vivo skin imaging
Friday, April 3, 2015 - 05:50
in Health & Medicine
Tape stripping is a commonly used method to increase the penetration depth of drug delivery. It has also been used to investigate the physiology of the stratum corneum (SC) as well as the kinetics and penetration depth of topical drugs. During the tape stripping process, the SC is sequentially removed by a serial number of stripping procedures. Yet, tape stripping induces mechanical disruptions of the epidermal barrier that lead to skin inflammation. Similar to many other inflammatory skin disorders, microvascular remodeling is usually involved. Surprisingly, little work has been done on revealing the microvasculature changes and/or to correlate the degree of the vascular reactions with the degree of damage produced.