Team engineers 'Cas9' animal models to study disease and inform drug discovery
Thursday, September 25, 2014 - 12:40
in Biology & Nature
Researchers from the Broad Institute and Massachusetts Institute of Technology have created a new mouse model to simplify application of the CRISPR-Cas9 system for in vivo genome editing experiments. The researchers successfully used the new "Cas9 mouse" model to edit multiple genes in a variety of cell types, and to model lung adenocarcinoma, one of the most lethal human cancers. The mouse has already been made available to the scientific community and is being used by researchers at more than a dozen institutions. A paper describing this new model and its initial applications in oncology appears this week in Cell.