Crystal structure of COP9 signalosome elucidated
Wednesday, August 13, 2014 - 05:30
in Biology & Nature
Nicolas Thomä and his group at the Friedrich Miescher Institute for Biomedical Research have elucidated the crystal structure of the human COP9 signalosome, an important regulator of protein degradation. The crystal structure, published in today's issue of Nature, provides detailed insights into the molecular architecture of the eight-subunit complex and explains how specificity is achieved.