Scientists shed light on how microRNAs repress protein synthesis
Monday, June 2, 2014 - 06:01
in Biology & Nature
(Phys.org) —Scientists from the Friedrich Miescher Institute for Biomedical Research have discovered how microRNAs repress translation of mRNAs. In a structure-function study published in Molecular Cell, they report different modes of recruitment of the CCR4-NOT complex to mRNAs targeted by microRNAs. They also demonstrate that CCR4-NOT recruits and activates the ATPase DDX6, an important translational inhibitor. Activation of DDX6 by CCR4-NOT plays a key role in miRNA repression.