Researchers unlock the secret of multiple insecticide resistance in mosquitoes
Friday, March 21, 2014 - 10:20
in Biology & Nature
Researchers at LSTM have discovered how unprecedented multiple and extreme-level resistance is generated in mosquitoes found in the rice fields of Tiassalé in southern Côte d'Ivoire. The paper, "CYP6 P450 enzymes and ACE-1 duplication produce extreme and multiple insecticide resistance in the malaria mosquito Anopheles gambiae" published in PLoS Genetics today, highlights the combination of stringently-replicated whole genome transcription profiling, in vivo transgenic gene expression and in vitro metabolism assays to identify and validate genes from the P450 detoxification enzyme superfamily which are highly expressed in the adult females from the area.