Proteomic analysis of tendon reveals disease stage-specific fragmentation of extracellular matrix proteins
Wednesday, February 12, 2014 - 09:31
in Health & Medicine
In a series of articles, researchers in the Tendon Biology group at the RVC have established the importance of inflammatory mediators in acute tendon disease and the reduced ability to resolve inflammation in chronic disease and in older individuals. In their most recent study published in the Journal of Biological Chemistry, Dr Stephanie Dakin from the group and collaborators at the University of Lund, Sweden, investigated the subtle protein cleavages induced by inflammation in normal and injured equine flexor tendons using a proteomics approach.