One pot, many possibilities: Synthesis of fluorine-bearing amine molecules

The trifluoromethyl group is present in many pharmaceutical and agrochemical products owing to its useful biological properties. A number of trifluoromethylated amine compounds display high bioactivity and are therefore of particular interest to medicinal chemists, but few synthetic methods for producing these compounds are known. Mikiko Sodeoka and colleagues from the RIKEN Synthetic Organic Chemistry Laboratory and RIKEN Center for Sustainable Resource Science have now developed a simple one-pot synthesis for a range of these important molecules.

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