Researchers learn from nature
Tuesday, February 5, 2013 - 06:20
in Biology & Nature
A research team of scientists from the European Molecular Biology Laboratory of Grenoble and the Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC) in Strasbourg have now, for the first time, succeeded in describing in molecular detail the architecture of the central scaffold of human TFIID, the protein complex essential for transcription from DNA to mRNA. The Human TFIID is a megadalton-sized multiprotein complex composed of TATA-box-binding protein (TBP) and 13 TBP-associated factors (TAFs). Despite its crucial role, the detailed architecture and assembly mechanism of TFIID remain elusive.