New dye could open the door to in vivo applications of fluorescence anisotropy
Friday, February 17, 2012 - 10:30
in Physics & Chemistry
(PhysOrg.com) -- US scientists have synthesized a polymethine dye that can be used for fluorescence anisotropy imaging in the near-infrared (NIR) spectral range, making new in vivo applications of this technique possible. Until now, the method has been limited to the visible part of the spectrum, mainly being used in drug selection and quality control of protein labeling. "Due to the deep penetration of near-infrared photons in biological tissues, fluorescence anisotropy could now be potentially utilized to monitor the behavior of drugs in living organisms", says Professor Mikhail Y. Berezin (Washington University), one of the authors of the work published in ChemPhysChem.