H5N1 virus targets pulmonary endothelial cells
Friday, January 20, 2012 - 09:31
in Health & Medicine
The H5N1 virus has killed roughly 60 percent of humans infected, a mortality rate which is orders of magnitude higher than that of seasonal influenza virus. Many victims of the former fall heir to acute respiratory distress syndrome—the inability to breathe. Now researchers from the Centers for Disease Control and Prevention, and the University of South Alabama show that the highly pathogenic avian influenza H5N1 virus, but not seasonal influenza viruses, can target the cells of human lung tissue, where they replicate fast and efficiently, and induce inflammation, which correlates with H5N1-induced acute respiratory distress syndrome that is observed in humans. The research is published in the January Journal of Virology.