Neuroscientists visualize neural circuitry at once-unattainable depths

A recent breakthrough in biological sample preparation by scientists at the RIKEN Brain Science Institute in Wako may give Astro Boy’s ‘x-ray vision’ a run for its money. By treating tissue samples with an easy-to-prepare mix of chemicals, Atsushi Miyawaki, Hiroshi Hama and their colleagues can render the brain and other tissues as clear as glass, a reversible transformation that gives researchers an unobstructed view of fluorescently labeled cells residing within1.

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