Sequenced genomes make good neighbors
Monday, January 10, 2011 - 19:00
in Biology & Nature
(PhysOrg.com) -- To study the proteomes of organisms, a first step often involves using sequenced genomes in conjunction with mass spectrometric measurements for global protein identifications. But, how do you identify the proteins in an organism yet to be sequenced? One way is to look at its sequenced neighbors, which is what scientists at Pacific Northwest National Laboratory (PNNL) did. They demonstrated a trans-organism search strategy for determining the extent to which near-neighbor genome sequences can be effective for global protein identifications in unsequenced organisms isolated from environmental samples.