Single-molecule technique captures calcium sensor calmodulin in action

It's well known that the protein calmodulin specifically targets and steers the activities of hundreds of other proteins - mostly kinases - in our cells, thus playing a role in physiologically important processes ranging from gene transcription to nerve growth and muscle contraction But just how it distinguishes between target proteins is not well understood. Methods developed by biophysicists at the Technische Universitaet Muenchen (TUM, Germany) have enabled them to manipulate and observe calmodulin in action, on the single-molecule scale.

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