Measuring Nanoparticle Behavior in the Body Using MRI

(PhysOrg.com) -- One of the key steps in the development of any drug or imaging agent intended for human use is measurement of the adsorption, metabolism, and excretion of the drug. Quantifying this collection of pharmacological properties, known as ADME, is a challenging and time-consuming process that is even more difficult when the drug or imaging agent includes a nanoparticle as one of its components. But by taking advantage of the magnetic properties of one kind of nanoparticle, a team of investigators at Washington University in St. Louis has demonstrated that they can measure ADME quickly using magnetic resonance imaging (MRI).

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