From Metabolism to Immunity: A Hidden Switch in Breast Cancer Uncovered
Monday, July 7, 2025 - 05:26
in Health & Medicine
In a surprising twist on cellular metabolism, scientists have uncovered a noncanonical role of the metabolic enzymePHGDH in shaping immune responses within breast cancer microenvironment. Acting from within the cell nucleus, PHGDH suppresses the activity of two critical genes--GLUD1 and GLS2--that drive glutamine metabolism, a pathway vital to immune cell function.