6-PPD Quinone at Environmentally Relevant Concentrations Disrupts Citric Acid Cycle in Caenorhabditis Elegans: Role of Reduction in Acetyl CoA and Pyruvate Contents
Wednesday, July 2, 2025 - 06:46
in Biology & Nature
Researchers explore how 6-PPD quinone (6-PPDQ), an environmental contaminant derived from tire antioxidant N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD), affects the citric acid cycle in C. elegans at environmentally relevant concentrations. The research reveals significant reduction in the citric acid cycle intermediates and key enzyme gene expressions by 6-PPDQ exposure, highlighting the its potential exposure risk on citric acid cycle metabolism.