How a Metabolic Pathway Promotes Breast Cancer Metastasis
Wednesday, April 6, 2016 - 16:30
in Health & Medicine
A metabolic pathway that is up-regulated in some breast cancers promotes the disease's progression by activating a signaling protein called Arf6, according to a paper published in The Journal of Cell Biology. The study, "P53- and mevalonate pathway-driven malignancies require Arf6 for metastasis and drug resistance" by Ari Hashimoto and colleagues, suggests that statin-like drugs may be effective treatments for breast cancer patients whose tumors express high levels of Arf6 signaling proteins.