Tension on Gut Muscles Induces Cell Invasion in Zebrafish Intestine, Mimicking Cancer Metastasis

Towards a better understanding of how tissue stiffness drives cancer, researchers show that epithelial cells lining the intestine of zebrafish with a mutation of the smooth muscle myosin gene form protrusions called invadopodia that allow the cells to invade surrounding tissue. The protrusions form in response to contractions in surrounding smooth muscle cells.

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