'Master controller' behind DNA structure reorganization during senescence identified
Tuesday, June 2, 2015 - 18:00
in Biology & Nature
Senescence, a phenomenon in which cells cease to divide and grow, can be caused by everything from natural DNA damage to treatment with chemotherapy. However, several mechanisms allow for cells to bypass senescence and grow out of control, eventually becoming cancerous. Now, scientists at The Wistar Institute have identified how a specific variant of a key protein complex found in human cells called condensin can reorganize a cell's genetic architecture in such a way as to promote senescence, making it an important facilitator in a cell's anticancer ability.