Noncoding RNA CCDC26 Regulates KIT Expression
A long noncoding RNA (lncRNA), which might give an impact on tyrosine kinase-targeted leukemia therapy, was found to be expressed in a leukemia cell line. The function of the lncRNA CCDC26 is not fully understood; however, researchers found the mechanisms by which CCDC26 controls the receptor tyrosine kinase KIT expression. Recent transcriptomic studies have revealed the existence of numerous RNAs that are relatively long but not translated into proteins. Some of such lncRNAs are suggested to regulate the expression of other genes. Mutations or imbalances in the noncoding RNA repertoire within the body can therefore cause a variety of diseases such as cancer. However, the molecular functions of lncRNAs remain to be fully elucidated. read more