New Clues To Origin Of Hirschsprung's Disease

Thursday, April 9, 2015 - 17:30 in Health & Medicine

Genetic studies in humans, zebrafish and mice have revealed that two different types of genetic variations team up to cause a rare condition called Hirschsprung's disease, flaws in early nerve development that lead to poor colon function which must often be surgically corrected. About one in every 5,000 babies is born with Hirschsprung's disease, which causes bowel obstruction and can be fatal if not treated. The disease arises early in development when nerves that should control the colon fail to grow properly. Those nerves are part of the enteric nervous system, which is separate from the central nervous system that enables our brains to sense the world. read more

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