Tumor Sanctuaries - The Cancer Therapy Breeding Grounds Of Resistance
Thursday, March 19, 2015 - 16:40
in Health & Medicine
Tumors acquiring resistance is one of the major barriers to successful cancer therapy. Feng Fu, Sebastian Bonhoeffer (ETH Zurich) and their collaborator Martin Nowak (Harvard) use mathematical models to characterize how important aspects of tumor microenvironment can impair the efficacy of targeted cancer therapies. Failure of cancer therapy is commonly attributed to pre-existing resistant mutants already present prior to treatment. However, the research publishing this week in PLOS Computational Biology highlights the important role of tumor sanctuaries in the rapid acquisition of resistance. read more