Neutralizing Cross-reactive Antibody Impacts 5 Staphylococcus Aureus Cytotoxins
Thursday, January 22, 2015 - 23:50
in Health & Medicine
Scientists have described a unique monoclonal antibody with the potential to treat Staphylococcus aureus (S. aureus) infections through the simultaneous neutralization of multiple key toxins produced by S. aureus, including alpha-hemolysin and four additional leukocidins. The findings are published online this week in the journal mAbs and demonstrate superior in vitro potency compared to antibodies targeting alpha-hemolysin alone. The mAb also shows high protective efficacy from lethal S. aureus infections in several animal models. read more