The Biological Clock Regulating Skin Stem Cell Metabolism

A study of circadian rhythms in skin stem cells finds that this biological clock plays a key role in coordinating daily metabolic cycles and cell division. The paper shows how the body's intrinsic day-night cycles protect and nurture stem cell differentiation and provides insights into a mechanism whereby an out-of-synch circadian clock can contribute to accelerated skin aging and cancers. Bogi Andersen, professor of biological chemistry and medicine at University of California - Irvine, and Enrico Gratton, professor of biomedical engineering, focused their efforts on the epidermis, the outermost protective layer of the skin that is maintained and healed by long-lived stem cells. read more

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