Rapamycin Vs. FK506 For Schwann Cell Migration And Peripheral Nerve Repair

FK506 possesses a well-studied neuroregenerative effect, stimulating neurite extension in the presence of nerve growth factor in vitro, and enhancing nerve regeneration following nerve crush injury and isografting. The use of FK506 to stimulate nerve regeneration is limited because of the risk of renal failure and hypertension, and its considerable cost.  With long-term allografts, FK506 alone or combined with other drugs reportedly cause life-threatening infections. Like FK506, rapamycin is an immunosuppressant and FKBP-12-binding ligand, and has a neuroregenerative effect in vitro. read more

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