Ionic Liquids: Busting Through Biofilm Shatters Defenses Of Serious Skin Infections

Biofilms are the first line of defense for harmful bacteria and make the treatment of skin infections especially difficult because microorganisms protected in a biofilm have antibiotic resistance and recalcitrance to treatment. Biofilm-protected bacteria account for some 80 percent of total bacterial infections in humans and are 50 to 1,000 times more resistant to antibiotics than simpler bacterial infections.  Biofilms often persist in the periphery of an actual wound, beneath an intact, healthy skin layer and the difficulty of their treatment is largely due to the outermost layer of the skin, the stratum corneum, being a natural barrier for drug delivery. read more

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