Trigger-Threshold-Target: Understanding Why Autism Potentially Occurs Needs An Overhaul

An analysis of autism research covering genetics, brain imaging, and cognition seeks to modernize our understanding of why autism potentially occurs, develops and results in a diversity of symptoms. The team calls it the “Trigger-Threshold-Target’’ model. Brain plasticity refers to the brain’s ability to respond and remodel itself, and this model is based on the idea that autism is a genetically induced plastic reaction. The trigger is multiple brain plasticity-enhancing genetic mutations that may or may not combine with a lowered genetic threshold for brain plasticity to produce either intellectual disability alone, autism, or autism without intellectual disability. read more

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