PPARgamma Receptor In The Brain May Curb Obesity

A new study in The Journal of Clinical Investigation (JCI) found that preventing weight gain, obesity, and ultimately diabetes could be as simple as keeping a nuclear receptor, PPARgamma, from being activated in a small part of the brain. When researchers blocked the effects of PPARgamma in a small number of brain cells in mice, the animals ate less and became resistant to a high-fat diet. Proopiomelanocortin (POMC) neurons are found in the hypothalamus and regulate food intake. When activated, these neurons cause a feeling of fullness and curb appetite. PPARgamma regulates the activation of these neurons. read more

Read the whole article on

More from