Antibiotics A Potential Mechanism For Autoimmunity

The code for every gene includes a message at the end of it that signals the translation machinery to stop but diseases like cystic fibrosis and Duchenne muscular dystrophy can result from mutations that insert this stop signal into the middle of an essential gene, causing the resulting protein to be truncated. Some antibiotics cause the cell's translation machinery to ignore the stop codons and are therefore being explored as a potential therapy for these diseases. New research in Proceedings of the National Academy of Sciences finds that this approach could come with the price of triggering autoimmune disease. read more

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