KCNK3 Gene Implicated In Pulmonary Hypertension

Researchers have identified new genetic mutations in the gene KCNK3 that can cause pulmonary arterial hypertension, a rare fatal disease characterized by high blood pressure in the lungs. The KCNK3  mutations appear to affect potassium channels in the pulmonary artery, a mechanism not previously linked to the condition. Cell culture studies showed that the mutations' effects could be reversed with a phospholipase inhibitor.   The effects of the KCNK3 mutations were reversed in cell cultures with an experimental phospholipase inhibitor called ONO-RS-082.  read more

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