A Treatment For Neurodegenerative Machado-Joseph Disease?
Monday, July 23, 2012 - 10:01
in Health & Medicine
Researchers have moved a step closer to find a treatment for the fatal neurodegenerative disorder Machado-Joseph disease (MJD) after a Portuguese team from the Centre for Neurosciences at the University of Coimbra was able to halt the brain degeneration in mice, by blocking a molecule called calpain. Calpain are known to cut ataxin-3 (the mutant protein behind MJD) into fragments, and the study proves that these fragments are crucial to trigger the neurodegeneration. read more