Response to Comment on "Innovative scattering analysis shows that hydrophobic disordered proteins are expanded in water"

Thursday, August 30, 2018 - 13:20 in Biology & Nature

Best et al. claim that we provide no convincing basis to assert that a discrepancy remains between FRET and SAXS results on the dimensions of disordered proteins under physiological conditions. We maintain that a clear discrepancy is apparent in our and other recent publications, including results shown in the Best et al. comment. A plausible origin is fluorophore interactions in FRET experiments.

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