Mechanism of controlling autophagy by liquid-liquid phase separation revealed
Saturday, February 15, 2020 - 15:40
in Biology & Nature
Scientists elucidated characteristics of PAS through observing the Atg protein using a fluorescence microscope and successfully reconstituted PAS in vitro. The team revealed, for the first time, that PAS is in the state of liquid droplets formed by liquid-liquid phase separation of Atg13 together with other Atg proteins and that this liquid droplet is responsible for autophagy.