Structure of a 'master switch' controlling cell division
Tuesday, May 28, 2019 - 22:24
in Health & Medicine
Unregulated cell division is a hallmark of cancer, and one of the key proteins involved in controlling cell division is called FoxM1. Abnormal activation of FoxM1 is a common feature of cancer cells and is correlated with poor prognosis, metastasis, and resistance to chemotherapy. Now researchers have determined the structure of this protein -- a kind of 'master switch' for cell division -- in its inactive or 'off' conformation.