Anti-inflammatory drug is the key to boosting cardiac reprogramming
Wednesday, March 6, 2019 - 14:40
in Health & Medicine
Researchers have developed a high-throughput screening system to identify the NSAID diclofenac as a factor responsible for enhancing cardiac reprogramming in postnatal and adult fibroblasts. Diclofenac functioned during early-stage reprogramming by silencing the cellular signature associated with fibroblasts and inhibiting COX-2 and other molecules associated with inflammation. Ant-inflammation could therefore be used to improve cardiac reprogramming associated with aging.