Inhibiting nuclear factor kappa B improves heart function in a mouse model of Duchenne muscular dystrophy
Thursday, August 30, 2018 - 19:50
in Biology & Nature
Researchers have uncovered an unexpected mechanism that underlies cardiomyopathy (heart failure) in Duchenne muscular dystrophy (DMD). They report that nuclear factor kappa B down-regulates calcium genes, contributing to cardiomyopathy in DMD. Furthermore, data from a mouse model show cardiomyocyte ablation of NF-kappaB rescues cardiac function.