Crystal structure reveals how curcumin impairs cancer
Monday, July 9, 2018 - 22:22
in Physics & Chemistry
Through x-ray crystallography and kinase-inhibitor specificity profiling, researchers reveal that curcumin, a natural occurring chemical compound found in the spice turmeric, binds to the kinase enzyme dual-specificity tyrosine-regulated kinase 2 (DYRK2) at the atomic level. This previously unreported biochemical interaction of curcumin leads to inhibition of DYRK2 that impairs cell proliferation and reduces cancer burden.