Researchers identify SH2 domains as lipid-binding modules for cell signaling
Monday, March 28, 2016 - 10:21
in Biology & Nature
Majority of human Src homology 2 (SH2) domains not only bind to proteins, but also interact with membrane lipids with high affinity and specificity. The SH2 domain-containing proteins play important roles in various physiological processes and are involved in cancer development. This study reveals how lipids control SH2 domain-mediated cellular protein interaction networks and suggests a new strategy for the therapeutic modulation of pY-signaling pathways.