Blood cancers develop when immune cell DNA editing hits off-target spots

Editing errors in the DNA of developing T and B cells can cause blood cancers. Now, researchers have shown that when the enzyme key to cutting and pasting segments of DNA hits so-called 'off-target' spots on a chromosome, the development of immune cells can lead to cancer in animal models. Knowing the exact nature of these editing errors will be helpful in designing therapeutic enzymes based on these molecular scissors, researchers say.

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