In vivo CRISPR-Cas9 screen sheds light on cancer metastasis, tumor evolution
Thursday, March 5, 2015 - 14:30
in Biology & Nature
For the first time, CRISPR-Cas9 gene-editing technology has been employed in a whole organism model to systematically target every gene in the genome. A team of scientists has pioneered the use of this technology to 'knock out,' or turn off, all genes across the genome systematically in an animal model of cancer, revealing genes involved in tumor evolution and metastasis and paving the way for similar studies in other cell types and diseases.