Researchers target rapid destruction of protein responsible for cancer cell resistance to therapy
Friday, August 15, 2014 - 05:01
in Health & Medicine
Researchers have identified an enzyme that may help break down chemoresistance in cancer cell that overexpress Myeloid Cell Leukema-1 (Mcl-1). The Mcl-1 protein is frequently over-expressed in cancer; it is present not only in leukemia and lymphoma but also in a host of solid tumors. While Mcl-1 is expressed in a highly-controlled fashion in normal cells, its over-expression and lack of destruction maintains the viability of cancer cells and renders them resistant to chemotherapy.