High doses of antibiotics may have potential to promote increased cross-resistance
Wednesday, June 25, 2014 - 11:21
in Biology & Nature
An experimental evolution approach has been used by researchers to evolve 88 different E. coli populations against 22 antibiotics, under 'strong' and 'mild' selection conditions. Results demonstrate that the evolution of cross-resistance depends on selection strength. Overall, they found evidence for higher cross-resistance in the strongly selected strains and higher numbers of pathway-specific mutations.