Customizing antibodies by learning from sharks

Genetically engineered antibodies are deployed successfully in cancer diagnostics and therapy. Therapeutic antibodies against Alzheimer's disease and multiple sclerosis are currently under development. An important criterion when designing suitable antibody fragments is their stability. Comparing the antibodies of sharks with those of humans, a team of researchers has discovered stabilizing mechanisms that can also be applied to optimize custom-tailored antibodies for medical applications.

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