How repeated aggression triggers social aversion in mice
Friday, January 18, 2013 - 20:00
in Health & Medicine
One of the mechanisms involved in the onset of stress-induced depression has been highlighted in mice. Scientists have determined the role of the corticosterone (stress hormone) receptor, in the long-term behavioral change triggered by chronic stress. In mice subject to repeated aggressions, this receptor participates in the development of social aversion by controlling the release of dopamine, a key chemical messenger. If this receptor is blocked, the animals become "resilient": although anxious, they overcome the trauma and no longer avoid contact with their fellow creatures.