New genetic mutation for amyotrophic lateral sclerosis identified

Tuesday, January 15, 2013 - 15:50 in Biology & Nature

Researchers have identified a new genetic mutation for amyotrophic lateral sclerosis (ALS), opening the door to future targeted therapies. Medical researchers found that mutations within the ARHGEF28 gene are present in ALS. When they looked across both familial and sporadic forms of the disease, they found that virtually all cases of ALS demonstrated abnormal inclusions of the protein that arises from this gene.

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