Potential treatment for lethal childhood leukemia: Inhibiting two related enzymes significantly improves survival in mouse model
Monday, April 16, 2012 - 15:31
in Health & Medicine
Researchers have demonstrated that two related enzymes -- phosphoinositide-3 kinase gamma and delta -- play a key role in the development of T-cell acute lymphoblastic leukemia, a highly aggressive childhood leukemia that is difficult to treat. The study also showed that a dual PI3K gamma/delta inhibitor can significantly prolong survival in a mouse model of the disease.