New insight into the cellular defects in Huntington's disease
Monday, October 10, 2011 - 13:30
in Biology & Nature
Huntington disease is a devastating neurogenerative disorder caused by a mutant HTT gene. Although this has been known for many years, the functions of normal Htt protein and the mechanisms by which mutant Htt protein causes disease are not well understood. But now, researchers have now uncovered a new function for normal Htt protein and determined that this function is disrupted in a mouse model of Huntington's disease and in patients with the disorder.