Paradigm Shift In Immune Response Regulation
Wednesday, March 25, 2009 - 22:35
in Health & Medicine
Over the past decade various pieces of the puzzle how signal transmission controls immunity have been coming together. Now, scientists report a paradigm shift in the regulation of immune response. Their results show that interaction with a linear ubiquitin chain is crucial for nuclear factor kappa B activation. Their findings may also contribute towards structure-based drug design to target the defective NF-kappa-B pathway in diseases such as cancer, inflammation and immunodeficiency.